Through derivatization and preparative GLC, guggultetrol-18 (48) (Figure 18) and guggultetrol-20 (49) (Figure 18) were obtained in pure form [23]. Dev S. A modern look at an age old ayurvedic drug guggulu. It found that the guggul-based cream improved skin symptoms, such as redness, inflammation, tenderness, and pain, as well as reduced the need for topical steroid creams for treatment (7). Karan M., Sarup P., Suneja V., Vasisht K. Effect of traditional ayurvedic purification processes (sodhanvidhi) of guggulu on carrageenan-induced paw oedema in rats. FIGURE 1 Figure 1. Ultimately, further research is warranted to confirm the link between guggul and weight loss. Initial studies reported that crude guggulu has encouraging hypolipidemic activity in rabbits [38]. (57, 58), Clinical trials are lacking to provide dosage guidelines; however, in a US clinical trial in hyperlipidemia, 75 mg to 150 mg of standardized guggulsterones were administered daily.51 1,000 mg capsules containing 21 mg of guggulsterones were used in this study. The steroidal constituents have been related with hypolipidemic and anti-inflammatory activities of the drug [13]. Heres what research says about these claims. (A) Commiphora (Mark W. Skinner/ www.discoverlife.org) and Gum guggul ( http://www.varionlife.com ). (55) In vitro antibacterial effects have been described. Academic Editor: Marie-Aleth Lacaille-Dubois. Other isolated cembrane type diterpenes include isocembrol (5) (Figure 3) and 4-epiisocembrol (6) (Figure 3). [5] It is often sold as a herbal supplement. WWII Bunker Where Japanese Scientists Tested Bio-Weapons on Prisoners Found Oleo-gum resin, guggulu, tapped from the stems of this species, is consumed in high volumes by the Indian herbal industries. Guggulu (resin from, Fatope M. O., Al-Burtomani S. K. S., Ochei J. O., Abdulnour A. O., Al-Kindy S. M. Z., Takeda Y. Muscanone: a 3-O-(1,8,14-trimethylhexadecanyl) naringenin from, Kakrani H. K. Flavonoids from the flowers of, Kumar V., Dev S. Chemistry of ayurvedic crude drugsVII guggulu (resin from, Su S.-L., Duan J.-A., Tang Y.-P., et al. Diterpenoid constituents from guggulu include-camphorene (1) (Figure 1) [10], cembrene-A (2) (Figure 1), cembrene (3) (Figure 2) [10], and other cembrenoids. Treatment with gugulipid significantly inhibited the viability of human prostate cancer cell line LNCaP (androgen-dependent) and its androgen-independent variant (C-81) with IC50 of 1M (24h treatment), thus indicating its possible role in apoptosis and cancer prevention [60]. Photo taken on Aug. 13, 2022 shows a roll of a . Some sources marketing products with gum guggul extracts on the Internet listed concentrations and suggested doses. Guggul is often claimed to help treat obesity by promoting fat loss and suppressing appetite. Guggulu is an oleo-gum resin which exudes out as a result of injury from the bark of Commiphora wightii (Arnott) Bhandari [syn. It is also found in forests of Karnal, FOIA Biological Source Guggal is a gumresin obtained by incision of the bark of Commiphora mukul (H. and S.) Engl., belonging to family Burseraceae. Effect of guggulsterone and cembranoids of. Guggul has been used in the traditional Ayurvedic medical system for centuries and has been studied extensively in India. It is cultivated mainly in Islands of Zanzibar, Pemba, Brazil, Amboiana, and Sumatra. The 50 percent aqueous methanolic extract was found to exhibit an anti-inflammatory effect on adjuvant-induced air pouch granuloma in mice. Isolation of several steroidal constituents has been reported from the gum resin. Your thyroid gland is responsible for growth and metabolism in your body. official website and that any information you provide is encrypted It has a wide range of usefulness in indigenous medicine. A pollen grain showing the nanofoam within or a diatom with the individual geometric structures inside clearly visible: Using high-energy X-rays from the PETRA III synchrotron light source at DESY . Guggul Supplement: Uses, Benefits, Side Effects, Dose - MedicineNet However, research is limited to dated animal and test-tube studies (33, 34, 35). In carefully planned studies carried out (over a period of two years) on rabbits, in which hyperlipidemia was induced by feeding cholesterol (in hydrogenated vegetable oil), it was demonstrated for the very first time that crude guggulu could not only lower significantly the serum cholesterol in hypercholesterolemic rabbits but also protected these animals against cholesterol-induced atherosclerosis at the fatty streak stage. 2023 Healthline Media LLC. C. mukul was extracted with alcohol and the extract after removal of the solvent was partitioned between water and ether. Guggulsterones E and Z are the chief bioactive constituents of this resin and are endowed with immense pharmacological value. This has led researchers to recommend that pregnant and breastfeeding women avoid guggul (17). The plants are the primary producers and an indispensible source of food and nutrition, medicine and fuel/biofuel. The broken mass is wrapped in a piece of cloth (called potli) and hanged into an inert container (called dola yantra) containing one of the recommended media which are gomutra (cow urine), triphala kasaya (decoction of triphala), vasapatra kasaya (decoction of Adhatoda vasica leaves), vasapatra savrasa (aqueous extract of Adhatoda vasica leaves), dugdha (milk), and water. (34) Guggulsterone also exerts a protective effect on cardiac enzymes against drug-induced myocardial necrosis. The findings of multicentric clinical trials carried out with gugulipid at seven different centres in India coordinated in collaboration with CDRI confirmed the role of gugulipid as a hypolipidemic agent [36]. Therefore, those with bleeding disorders, as well as people undergoing surgery or taking medications that affect blood clotting, should avoid its use (30). Guggulsterones, the lipid-lowering components of guggulu, effectively inhibited in vitro LDL oxidation (as discussed under antioxidant action). National Library of Medicine Medically reviewed by Drugs.com. The history of guggul goes as far back as 1700 BC. In rats with isoproterenol-induced ischemia, a hydroalcoholic extract of C. mukul improved cardiac function and prevented myocardial ischemic impairment. Knowing which type of acne you have is key to successfully clearing it from your skin. New high resolution X-ray imaging technique can image biological Guggul can also cause allergic reactions such as rash and itching. Overview Guggul is made from the oily sap (gum resin) of the guggul tree (Commiphora wightii). It can cause side effects such as stomach upset, headaches, nausea, vomiting, loose stools, diarrhea, belching, and hiccups. One dated study in 21 people found that taking 25 mg of guggulsterone orally was as effective as tetracycline, an antibiotic commonly used to treat acne (4). Commiphora wightii (Arn.) Guggulsterone (50M) prevented the generation of thiobarbituric acid reactive substances and lipid hydroperoxide of low density lipoprotein in above system. Matsuda H., Morikawa T., Ando S., et al. It is gynodioecious, with some plants bearing bisexual and male flowers, and others with female flowers. Yu B.-Z., Kaimal R., Bai S., et al. This information should not be used to decide whether or not to take this product. MM College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 132 037, India. The major constituents include E-guggulsterone (23) (Figure 11), Z-guggulsterone (24) (Figure 11), guggulsterol-1 (25) (Figure 12), guggulsterol-II (26) (Figure 12), guggulsterol-III (27) (Figure 12) [18], guggulsterol-IV (28) (Figure 13), guggulsterol-V (29) (Figure 13) [19], and guggulsterol-VI (30) (Figure 13) [20]. Guggul Scientific Name (s): Commiphora mukul Hook. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The https:// ensures that you are connecting to the Figure 14. Still, research is limited, and more studies are needed to confirm gugguls purported benefits for skin health. Studies have shown that the guggulsterones are antagonist ligands for the bile acid receptor farnesoid X receptor, which is activated by bile salts, thus reducing cholesterol. An official website of the United States government. Results showed that this treatment significantly improved signs and symptoms associated with hypothyroidism, such as weakness, fatigue, and muscle aches (11). These compounds constitute a new class of naturally occurring lipids, guggultetrols. Some of the major species include Commiphora wightii, Commiphora. These Science-Backed Tips Can Help You Lose Weight Sustainably, What You Should Know About Hyperlipidemia. Guggulsterone antagonized the chenodeoxycholic acid-activated nuclear farnesoid X receptor (FXR), which regulates cholesterol metabolism in the liver. Its most well marketed effect, that of being able to increase thyroid activity, does not occur with doses commonly found in supplements. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. The tree is a small shrub with thorny branches. Guggul contains a mixture of plant compounds, including steroids, essential oils, lignans, flavonoids, carbohydrates, and amino acids all of which may be responsible for its various health effects. This preparation is derived from the gum resin (guggulu) of the tree Commiphora muku. Guggul is the gum resin obtained from a variety of plants native to India, Bangladesh, and Pakistan. Accessibility Due to the lack of human studies regarding the safety and efficacy of guggul, you may experience some side effects that have not been widely reported. Guggul: Benefits, Dosage, Side Effects, and More - Healthline It also enhanced the production of thyroxin and triiodothyronine; these hormones increase the metabolism of carbohydrates and protein synthesis and help in lowering the lipid activity [47]. C. mukul is synonymous with Commiphora wightii and is in the same genus as Commiphora myrrha, the myrrh mentioned in the Bible.1, 2, The plant has been used in the traditional Ayurvedic medical system for centuries in the treatment of a variety of disorders, most notably arthritis, and as a weight-reducing agent in obesity. Several animal studies have demonstrated the effectiveness of guggulu extract in standard osteoarthritis (OA) models. Ex Stocks) Engl; Balsamodendron mukul (Hook. Additionally, one recent double-blind, placebo-controlled study found guggul statistically ineffective at lowering blood sugar levels in people with type 2 diabetes (22). (2), Positive effects on neuroinflammation, memory impairment, and dementia-related memory deficit in animal models suggest potential benefits in Alzheimer disease dementia. During the process of purification, foreign matter is removed from raw guggulu manually and is then broken into small pieces. Nityanand S., Srivastava J. S., Asthana O. P. Clinical trials with gugulipida new hypolipidaemic agent. Avoid exposing the product to light, heat, and moisture. In vitro studies and clinical trials help improve and advance medical care. Geographical source : Plant is . The site is secure. Phytochemical Constituents of Guggul and their Biological Qualities Monitor therapy. Although the results from these studies seem promising, more up-to-date research is warranted before strong conclusions can be made. In the herbal drug pharmaceutical industry, guggul is enjoying emergent consumer acceptance around the world. Eczema and psoriasis are both noncontagious skin conditions that are mainly caused by inflammation of the skin. All the fractions were found to lower the serum cholesterol, with fraction A being the most potent and fraction B being the least potent. Guggulsterone (4,17 (20)-pregnadiene-3,16-dione, Figure 14) is the active component of gugulipid. The cembrenoids did not show a noticeable effect on FXR but lowered the cholate-activated rate of human pancreatic IB phospholipase A2 (hPLA2), which controls gastrointestinal absorption of fat and cholesterol [44]. This review clearly authenticates the Sanskrit definition of the term guggul which means one that protects against diseases. This simple 3-step plan can help you lose weight fast. Guggul is a plant which is known for its active ingredients, the guggulsterones. (PDF) Commiphora wightii (Arnott) BhandariA Natural Source of Karan M., Kumar V., Suneja V., Vasisht K. Commercial herbal anti-inflammatory formulationsa survey. The active ingredients responsible for the maintenance of healthy. Bethesda, MD 20894, Web Policies Detailed description regarding its actions, uses, and indications and the varieties of guggul have been described in numerous Ayurvedic treatises including Charaka Samhita (1000 B.C. The shloka deals in an extraordinarily lucid and scientific manner, with the etiology, pathogenesis, and treatment of obesity and associated lipid disorders and their complications. [6] It is also sold in the form of incense sticks and dhoop cones which can be burned directly. Guggulu is a versatile drug and, because of its paranormal properties, it is very valuable in treating variety of disorders. A commercial product, Guggulow, claiming cholesterol-lowering properties, is widely available on the internet.2, 3, 4. Guggulu fraction A (pet ether extract) in daily dose of 1g was administered to healthy individuals (group I) and to patients of coronary artery disease (CAD) (group II) for a period of 30 days. For this reason, its recommended that people with liver disease exercise caution when using guggul (1, 24, 25). This study showed significant decrease in total cholesterol and LDL cholesterol after treatment with guggulu [40]. Biological Source Clove consists of the dried flower buds of Eugenia caryophyllus Thumb., belonging to family Myrtaceae. However, several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone and levels of low-density lipoprotein ("bad cholesterol") increased in many people. It has been mentioned in Ayurvedic texts that administration of raw guggulu may sometimes lead to skin rashes, irregular menstruation, diarrhoea, headache, mild nausea, and, with very high doses, liver toxicity [5]. The site is secure. Clinical trials are lacking to provide dosage guidelines; however, in a US clinical trial of hyperlipidemia, 75 to 150 mg of standardized guggulsterones were administered daily. The .gov means its official. The effect of guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease was studied. The IUCN includes, the species facing a high risk of extinction in the wild as threatened, and "endangered" is one of the sub . Guggul: An Herbal Preparation with Many Health-giving Uses Guggul. They have been isolated from cytotoxic fraction of ethyl acetate extract of guggulu. Pharmacological results have validated the use of this plant in the traditional medicines. It is a complex mixture of various classes of chemical compounds such as lignans, lipids, diterpenoids and steroids (Hanus et al . Three new and recently isolated steroids are guggulsterone-M, dihydro guggulsterone-M (36) (Figure 14), and guggulsterol-Y (37) (Figure 14) [17]. Biological cleanup discovered for certain 'forever chemicals' Two species of naturally-occurring bacteria found to breakdown chlorinated 'forever chemicals,' AKA PFAS Date: May 31, 2023 Source: The allylcembrol structure was established by spectral analysis and mild dehydration which yielded cembrene. Guggul sap, also referred to as guggul, gum guggul, guggula, or gugulipid, is tapped from the plants similarly to how maple syrup is extracted from maple trees. The leaves are simple or trifoliate, the leaflets ovate, 15cm (0.391.97in) long, 0.52.5cm (0.200.98in) broad, and irregularly toothed. It has been shown to be effective in both complementary and alternative treatments for nodulocystic acne, a severe form of acne affecting the face, chest, and back (3). Commiphora mukul), commonly known as guggul is one of the most valued medicinal plants having several pharmaceutical applications (Atal et al., 1975).Gum resin of this plant is an article of commerce in India. Plants in collaboration with their rhizobacteria partners are also exposed to these contaminants. The gum resin of C. wightii yields about 0.4% of essential oil by steam distillation and its chief components are myrcene, dimyrcene, and polymyrcene [8]. Price: $65 Purchase PDF Abstract In the herbal drug pharmaceutical industry, guggul is enjoying emergent consumer acceptance around the world. Phospholipase, xanthine oxidase, and lipid peroxides were simultaneously enhanced in ischemic heart following depletion of glycogen, phospholipids, and cholesterol. It has also been used to promote weight loss, treat hypothyroidism, and manage cholesterol and blood sugar levels (2). Pterocarpus - Pharmacognosy Additionally, those treated with guggul increased their walking distance (19). The resin of C. wightii, known as gum guggulu, has a fragrance similar to that of myrrh and is commonly used in incense and perfumes. Therefore, supplementation in this population should be avoided unless its directed by a healthcare professional. The aqueous fraction was chromatographed and it showed the presence of various amino acids. A report also states that, out of 22 individuals receiving 2160mg guggulu daily for 12 weeks, 10 persons experienced one or another side effect including gastrointestinal distress, fatigue, and skin rash [69]. Some animal research indicates that guggul may help reduce triglyceride, total cholesterol, and LDL (bad) cholesterol levels (15, 16). The dried mass is called purified guggulu (suddh guggulu) [1]. The gum-resin is also reported to possess marked cholesterol- and triglyceride-lowering activity (Pachnanda et al., 1980). None identified. Medicinal Plants of Conservation Concern: https://en.wikipedia.org/w/index.php?title=Commiphora_wightii&oldid=1127621092, IUCN Red List critically endangered species, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 15 December 2022, at 19:20. (2, 25, 26, 27, 28, 29, 30, 31, 32, 33) Induction of apoptosis and inhibition of angiogenesis and cell signaling, as well as the down-regulation of transcription factors, have all been demonstrated. Progesterone and related steroids, 4-pregnene-3,16-dione (32) (Figure 13), (20R)-20-acetoxy-4-pregnene-3,16-dione,16-acetyloxypregn-4,17(20)-trans-diene-3-one (33) (Figure 14), 3-acetyloxy-5-pregnan-16-one (34) (Figure 14), and 20R,22R-dihydroxycholest-4-en-3-one (35) (Figure 14), have also been isolated [16]. One older study in 30 people with knee osteoarthritis who were treated with guggul showed improvements in knee pain and knee swelling, as well as increased knee flexion (19). Nevertheless, more research is needed to understand the effect of guggul on cholesterol levels in humans. (11, 19, 20, 21), In mice with induced colitis, guggulsterone decreased the severity of the inflammatory disease. Although generally accepted as relatively safe, case reports of adverse events exist. Guggulsterone - an overview | ScienceDirect Topics Guggul: Uses and Risks - WebMD The absolute stereostructure of myrrhanol A was determined to be (3S, 5S, 8R, 9R, 10S)-3,8,30-trihydroxypolypoda-13E, 17E, 21E-triene. Received 2015 Jun 18; Revised 2015 Aug 28; Accepted 2015 Sep 7. The metal chelating capacity of guggulsterone might be contributing to its antioxidant activity [56]. Some of the major species include Commiphora wightii, Commiphora gileadensis, Commiphora mukul, Boswellia serrata, and Boswellia sacra. BhandariCommon Name(s): Guggal, Guggul, Guggulu, Gugulipid, Gum guggal, Gum guggulu, Indian bdellium, Indian myrrh. 1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Guggulu occurs in vermicular pieces of pale yellow or brown coloured mass with aromatic odour and bitter astringent taste; when fresh it is viscid and golden coloured. Commiphora mukul (Hook. In order to overcome unwanted effects of raw guggulu, Ayurveda describes a number of purification processes (shodhan vidhi) using different fluids (dravyas), which not only take care of the adverse effects but also enhance the therapeutic activity. It should produce not more than 5 percent of total ash and 1 percent of acid-insoluble ash. Commiphora wightii - Wikipedia 10.2305/IUCN.UK.2015-2.RLTS.T31231A50131117.en, "Guggul: Uses, Side Effects, Interactions, Dosage, and Warning", "Modulation of proinflammatory cytokines and enzymes by polyherbal formulation Guggulutiktaka ghritam", "Guggulipid Ineffective for Lowering Cholesterol", "Kutch to house Centre's Rs 8-cr Guggal conservation project", "Education and Awareness in the 'Save Guggul Movement'. No mutagenesis or teratogenicity has been described for gum guggul.2. mukul. There is little or no information on toxicity with the use of guggulu. Singh B. Figure 5), and C (12) ( Biological source: Guggal belongs to the oleogum resin category and obtained from Commiphora weightii, Commiphora Mukul by making a deep incision at the basal part of stem bark. This study did not report any intestinal distress [70]. Commiphora wightii, with common names Indian bdellium-tree, gugal, guggul, gugul, or mukul myrrh tree, is a flowering plant in the family Burseraceae, which produces a fragrant resin called gugal, guggul or gugul, that is used in incense and vedic medicine (or ayurveda).The species is native to southern Pakistan and western India. Pharmacology and Phytochemistry of Oleo-Gum Resin of Guggul Guggul is also known as "Pura" which means "wards off disease". As with any supplement, if youre currently taking medications, consult your healthcare provider before starting to take guggul. Commiphora wightii is sought for its gummy resin, which is harvested from the plant's bark through the process of tapping. People in India have used it for thousands of years as an herbal medicine. Available for Android and iOS devices. Sangle V. D., Nadkarni S. D., Vahalia M. K., Darp M. S. The study of effect of ayurvedic processing of, Saxena V. K., Sharma R. N. Constituents of the essential oil from, Rcker G. Monocyclic diterpenes from Indian gugul resin (. In view of this, guggulu fraction A may be a useful therapeutic agent in the management of coronary artery disease [46]. The provisional structure showed the gum to be a highly branched polysaccharide containing 16, 13, and 15 type of linkage [27]. In a study evaluating the anti-inflammatory effect of guggul, 500 mg of gum guggul was used 3 times daily.24. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oleo gum resin secreted by Commiphora mukul, also known as gum guggul, has been used widely as an ayurvedic drug. Additionally, administration of guggulu partially reversed the atherosclerosis in the aorta that was induced by high-fat diet [39]. Over-the-counter dosages of guggul appear to be relatively safe, as long as theyre taken as directed on the packaging. Guggulsterone significantly inhibited the reaction of lipid peroxidation in liver microsomes challenged with Fe2+ and sodium ascorbate. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Biological Source It consists of dried juice obtained by making vertical inci-sions to the stem bark of the plant Pterocarpus marsupiumLinn., belonging to family Leguminosae. This article, From mental health to how our body stores fat, recent research is adding to the body of evidence that illustrates how much sleep deprivation can, and. Language links are at the top of the page across from the title. These observations provided rationale for further preclinical and clinical evaluation of guggulsterone for its efficacy against prostate cancer [61]. The alcoholic extract could lower the cholesterol by 59.2 percent, whereas the terpenoid lowered it by 54.3 percent [38]. Putting the 'Oak' More Than 40,000 of Them in Oak Hill Figure 5), myrrhanone A (13) (Figure 6), myrrhanone B (14) (Figure 6) [14, 15], myrrhanone A acetate (15) (Figure 6), commipherol (16) (Figure 7), commipherin (17) ( The oxidation of human LDL induced by Fe2+ or by rat peritoneal macrophages caused marked formation of lipid peroxidation products. Here are the different types of pimples and how to treat them. Therefore, taking guggul in conjunction with these medications may decrease the drugs effectiveness (28). Inclusion in an NLM database does not imply endorsement of, or agreement with, Guggulu may decrease hepatic steroid production which ultimately increases the catabolism of plasma LDL cholesterol. Clinical Overview Use (35), In an older trial, C. mukul in combination with Inula racemosa (another Ayurvedic botanical) was studied in 200 patients with ischemic heart disease and found to improve electrocardiogram readings and decrease episodes of dyspnea and chest pain. Purported to have anti-inflammatory and antioxidant properties, it has been used in ancient medicine to protect against a variety of diseases. The hypolipidemic activity of the isomers E-guggulsterone and Z-guggulsterone has also been studied in animal models. The clinical trials done with standardized gum guggul extracts reported transient side effects such as skin rashes, diarrhoea, and irregular menstruations [33]. However, in a study conducted in a US population, increases in low-density lipoprotein (LDL) were observed, and case reports of increased LDL with guggul consumption exist. However, not all outcome measures showed improvement at the 2-month point. (2, 46), Limited quality clinical trials have been conducted, with the majority of studies in eastern Indian populations. These conclusions could open a new window on the use of this plant in Ayurveda. We comply with the HONcode standard for trustworthy health information. The antioxidant property of guggulu helped stop the oxidation of cholesterol and subsequent hardening of the arteries, reduced the stickiness of platelet, and also lowered the risk of coronary artery disease [45]. Serum fibrinolytic activity increased, while the platelet adhesive index decreased, which was statistically significant in healthy individuals and in CAD patients. (16), Down-regulation of the expression of inflammatory mediators, including interleukins, transcription factors and cytokines, and hyaluronidase and collagenase enzymes have been demonstrated for extracts of C. The results of this study indicated that guggulsterone inhibited proliferation of PC-3 cells in culture by causing apoptosis, whereas a normal prostate epithelial cell line is resistant to growth inhibition and apoptosis induction by this phytoconstituent. Oleo gum resin extracted by incision of the bark is a very complex mixture of gum, minerals, essential oils, terpenes, sterols, ferrulates . Theres limited research regarding the use of guggul in children and adolescents. (67, 68) Until larger, long-term quality trials have been conducted and the incidence of adverse events clarified, C. mukul extracts cannot be routinely recommended for the management of hyperlipidemia. Demonstrated biological effects of gum guggul extracts on lipid metabolism, thyroid hormone homeostasis, female reproductive tissues, endogenous nuclear hormone receptors and the potential for . One of the authors, Prerna Sarup, gratefully acknowledges the University Grants Commission for the grant of RFSMS fellowship. Can Ayurvedic Medicine Be Used for Weight Loss? Research reveals little information regarding toxicology with the use of guggul. Last medically reviewed on August 12, 2020, Ayurvedic medicine is a holistic, prevention-oriented healthcare approach. Phytochemical constituents of guggul gum and their biological qualities It has been mentioned in Ayurvedic texts that administration of raw guggulu may lead to skin rashes, irregular menstruation, diarrhoea, headache, mild nausea, and, with very high doses, liver toxicity [5].
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