Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy. Pharmaceutical compounds distribution and cosmetic products analyzed by confocal Raman spectroscopy. These include Fluorescence spectroscopy for photoactivity, Particle Size analysis for composition and Raman microscopy for formulation investigation. nanoGPS Suite solution allows a colocalized combination of a variety of microscopy techniques, providing a full characterization of nanostructured materials and a precise superimposition of the results obtained. Using Chemometrics and Raman Spectra for Quantitative Predictions of Physical and Chemical Properties of Polymers. Fast and non-invasive methods for clinical and non clinical investigations for biological tissue are more and more required. By coupling this technique with the Raman spectroscopy z-Scan analysis it is possible to acquire important information concerning the fabrication of smartphone screen protectors. Raman spectroscopy adapts to the different stages of life of these batteries, such as the characterisation of new materials for more flexible systems, failure analysis; but also more standard analysis of used material during charge/discharge process, including structural and electronic properties, and even robust, automated QC tests. However, greater objectivity is mandatory for identification and dating purposes. Morphological and chemical characterizations of microplastic particles using ParticleFinder and Raman techniques. Coloured Diamond Defect Idenditication by Raman Diffusion and Photoluminescence. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, in order to demonstrate the significance of the technique. Raman Analysis and characterization of pharmaceuticals. Natural rocks composing the Earth are complex. Not only defects concentration but also local chirality changes from the different radial breathing modes, pressure effect and strain distribution can be studied at the single carbon nanotube level through TERS. In this application note, SERS is used to study the behaviour of glycoprotein IIb3 which plays a critical role in thrombosis (pathological blood clotting which can reduce or completely stop blood supply to tissues and organs, leading to myocardial infarction or stroke). The Raman effect allows fast, non-destructive chemical analysis of solids, powders, liquids, and gases. milks. application notes and articles, and get new perspectives on your lab research. Multilayer polymer films, composed of different materials, are used in a variety of industrial applications. Raman spectroscopy shows high potential in combination with chemometric methods to investigate bulk samples, as well as a single cell, for discrimination purposes: Healthy and diseased cells distinction based on chemical and/or structural properties, and bacteria/yeasts classification up to strains level. Its been more than a decade that Raman spectroscopy has been recognized as an efficient and powerful analytical tool in the field of Forensic Science. Use this form to contact our specialists. Characterization of protective mask fibers by Raman microscopy. Raman Academy - Read - HORIBA In the food industry, the compounds characterization is a critical step to ensure the quality of the products or to provide information to customers which can be sensitive to allergies. Raman Spectroscopy has many useful properties which can be explored and exploited in the analysis of pharmaceutical formulations. In addition, definition of the crystalline phase has become as important as molecular composition in patent protection. There are many industries that need analytical instruments to control their products. In situ characterization of heterogeneous catalytic reactions. Plastic pollution from fishing gear is a global problem that harms the environment. The correlation between knowledge about structure with physical and chemical properties about the tubes make the technique extremely powerful to control the quality of the SWCNTs for specific applications. Transmission Raman spectroscopy: review of applications, Concentration profile measurements in polymeric coatings during drying by means of Inverse-Micro-Raman-Spectroscopy (IMRS), Raman imaging of holographic gratings inscribed on polymer thin films. In this study we have chosen to investigate pyrite and its surrounding minerals in order to identify the different mineral phases as well as the chemical variations from micro- to nano-scale. Raman spectroscopy of pharmaceutical ingredients under humidity controlled atmosphere. The recent development of side-illuminated TERS analysis even provides the possibility to investigate the behavior of graphene-based structures under device operation. Assessing Biotherapeutics Stability using Raman Spectroscopy. PDF Application Raman Microscopy Applied to Raman Polymer - Horiba Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field. Kelvin probe measurement supports TEPL and TERS measurements and adds to the power of such tip-enhanced combinative tools. Also, to avoid those properties of sugar, it has been replaced by sweeteners. Do you have any questions or requests? The intensity of the 1st diffracted orders is monitored to have equal intensities in both X and Y directions. Encountered difficulties are linked to the samples themselves which are unique, in very small amount and need to be handled as little as possible. Furthermore, strict regulatory and manufacturing procedures demand precise characterisation of a solid salt form drug candidate and the possible influence of environmental conditions. The LabRAM Odyssey replaces the best seller LabRAM HR Evolution. in this case, the inequivalent reaction rates of the two monomers. Disinfecting your hands with hydroalcoholic gel has become a daily practice. Thus, in this application note, the identification and chemical characterization of aeroallergens by Raman microscopy will allow to prevent people who are affected by respiratory allergies of the presence of this type of allergens in indoor and outdoor air. Recently, this interest in the contamination of aquatic systems by plastics has shifted to smaller particles, microplastics. Especially when one deals with examinations of evry small sample amounts or wishes to perform non-destructive analysis, e.g. Vibrational spectroscopic characterization can take place all along the catalyst life from the control of the synthesis of the precursor to the cpntrol of the catalyst regeneration via the analysis of the surface reaction mechanism. With the increase of allergic disorders over the past years, fast and reliable techniques for characterization and identification of pollen types are required. Valuable analysis tool for cosmetics and skin characterization. The atmosphere contains a large variety of particles in suspension (aerosols) that differ in chemical composition as well as in size distribution depending on the region of the atmosphere, the meteorological conditions and the anthropogenic activity. Using the different microscopes instruments and being co-localized allows a comprehensive characterization of the sample and a precise superimposition of all the images. In this article, we present how our Raman and X-Ray Fluorescence microscopies can be combined to shed some light on the origins of the universe. As shown by this example, these results can provide unexpected information on the details of the reaction. Raman spectroscopy and scanning electron microscopy confirm ochre residues on 71 000-year-old bifacial tools from Sibudu, South Africa. In vitro monitoring of time and dose dependent cytotoxicity of aminated nanoparticles using Raman spectroscopy. Rapid detection of drugs and explosives for forensic analysis. Each mineral can be defined by its chemical composition and its crystalline structure, and sometimes can also contain fluid inclusions. In recent years, core-shell particles have attracted significant attention due to their smart properties. Application Notes FLUO, RA, PSA 02: Spectroscopic methods for sunscreens characterization RA PSA 01: Particle characterization by optical spectroscopies and laser diffraction RA69: Soap compound investigation by Raman mapping Publications " Raman Spectroscopy and Polymorphism. This approach, that minimizes sample preparation and culture time, would allow resuming culture after identification to perform downstream antibiotic susceptibility testing. When exposed to warm and humid weather over time, ingredients may undergo change in their hydration level, thus affecting the properties and/or efficiency of the drug. Raman characterization of painted mortar in Republican Roman mosaics. Raman Spectroscopy was evaluated as a non-invasive method of analysis of sperm DNA and the influence of UV irradiation on the sperm. PISCATAWAY, NJ HORIBA Scientific, world leader in Raman microscopy, announces the new LabRAM Odyssey, a fully automated and remotely controllable system. In a quiet NYC neighborhood, a frustrated artist created forgeries of Americas Modernistic masters. Raman microprobe spectroscopy is an ideal candidate for this type of studies. Raman and photoluminescence spectroscopy and imaging are used to examine the spatial variation of solid state structure and electronic character of two dimensional (2D) WS2 crystals. Determination of extremely low concentration of sucrose in aqueous solution by Raman spectroscopy. Do you have any questions or requests? Combined Raman and Photoluminescence Imaging of 2D WS2. Raman spectroscopy is well known as a powerful analytical method for qualitative chemical analysis. We show some examples on a meteorite piece and on water inclusion in quartz matrix. Whats Protecting Your Mobile Screen? Bipolar plates are key components of proton exchange membrane fuel cells they notably distribute fuel gas and air and conduct electricity. The analysis of these multilayers is important to support, especially for safety and performances control. The Raman effect is highly sensitive to slight differences in chemical composition and crystallographic structure. During the last 5-10 years, the molecular solid state has gained recognition by the pharmaceutical industry for its role in drug manufacturing, stability, and activity. The use of the transmission raman mode instead of the traditional backscattering one brings additional flexibility for the analysis of material, especially when averaged information of bulky samples is required. The scientific community is increasingly interested in environmental contamination by plastics. The non destructive and in-situ analysis of pigments. In addition, scientific expertise is mandatory for identification, dating and detection for falsification purposes. Photoluminescence emission and Raman response of monolayer MoS, Co-localized microscopy techniques for pyrite mineral spatial characterization, Study of geological materials with Raman Spectroscopy, Coloured diamond defect identification by Raman diffusion and photoluminescence. Raman spectroscopic analysis of geological and biogeological specimens of relevance to the ExoMars mission. Here, we demonstrate that Raman spectroscopy is one solution to identify and evaluate sugar/sweetener concentrations in a quality control process. Graphene Studies using Raman Spectroscopy. in forensic laboratories or analysis of art paintings. Excipients and active pharmaceutical ingridients (APIs) can be analysed within seconds, and extensive Raman spectral libraries allow easy chemical identification. Raman imaging of a millimetre-sized core-shell SiO2@TiO2 sphere. Sugar content of those drinks must be regulated. Raman applications span many industries. The PL signature of green and violet diamonds has also been recorded. " Tuschel D. (2019). The results show that Raman Spectroscopy, combined with multivariate analysis provide the reproducible and accurate information on DNA of sperm and the effect and location of damage. Real-time Monitoring of Polymerisations in Emulsions by Raman Spectroscopy - Modelling and Chemometrics. The first part of this note concerns the dispersion of the two components in a polyethylene-polybutylene terephthalate blend. Traditionally, Raman has been a technique of the material scientist, physicist or chemist, but as instrumentation continues to evolve, the power of Raman in biological and medical applications is fast being realized, not least because of the high information content provided and an excellent tolerance for water. In many cases Raman spectroscopy is the technique of choice for characterization of carbon materials. The chemical imaging capabilities of the LabRAM will be used to get this information. In this application note, we showed how optical spectroscopies and laser diffraction can help for food compounds characterization, especially on a specific product, i.e. Leading experts in archeology and the arts base their certification of ancient artifacts on stylistic analysis and personal sensory perceptions. In order to engineer materials with controlled diffusive properties, we need to be able to measure the diffusive process in situ. An automated Raman-based platform for the sorting of live cells by functional properties. Results from this study identified specific Raman signature bands in this protein that can be used to identify individual amino acid residues that are reflect structural changes in proteins. Correlation of Raman spectral features with tribological properties can facilitate the deposition of carbon films. Their dimensions range from a few nanometers to tens of micrometers and their atmospheric life time can be as long as several weeks so that they can impact the global as well as the regional climates. Spectroscopic Methods for Sunscreens Characterization. Study of geological materials with Raman Spectroscopy. In this paper, we present why confocal Raman microscopy is an excellent tool for product characterization after formulation. Non-invasive on-site Raman study of blue-decorated early soft-paste porcelain: The use of arsenic-rich (European) cobalt ores Comparison with huafalang Chinese porcelains. Thus, Raman spectroscopy can be applied to large markets such as energy, environment, polymers and life sciences, to name a few. Raman Spectroscopy is a powerful and widely used analytical tool within the pharmaceutical industry. Both TEPL and TERS images are well correlated with AFM morphological images obtained simultaneously, and all are consistent in revealing the nature (number of layers) of MoS2 flakes. To overcome this major public issue, innovative analytical characterization tools such as microRaman spectroscopy are required. Raman spectroscopy offers specific features which are key points for life sciences analyses: its a non-invasive, label-free technique with a sub-micron spatial resolution. The natural scientific identification of pigments has some problems because of their insolubility in common solvents. As far as polymeric fibres are concerned, slight modifications of Raman features are directly related to differences in the molecular orientation and the degree of crystallinity of the fibres. PDF Solid State Application Note 03 - static.horiba.com
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