Cabbage. Early symptoms such as stiff joints and fatigue may be due to conditions other than hemochromatosis. Turmeric cream and HH any help in bringing down iron or saturation? I was excited to use turmeric, but searched for clinical research on it. According to the FDA, turmeric is generally regarded as safe. Specifically, oxidative stress is one of the most impactful problems of hemochromatosis and is a primary reason liver cells become less healthy. I started taking it and my numbers increased. These studies looking at turmeric and piperine are not using food; they use the extracted, concentrated chemical constituent derived from black pepper. Right? In addition to superior absorption, a topical skin application is easy and convenient to use. And thats not all that turmeric can do for us! Inflammation. Hemochromatosis Demystified Online Course, why you shouldnt use black pepper with turmeric, https://pubmed.ncbi.nlm.nih.gov/17897073/, https://pubmed.ncbi.nlm.nih.gov/16545682/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615657/, https://pubmed.ncbi.nlm.nih.gov/18651292/, https://pubmed.ncbi.nlm.nih.gov/17116705/, https://pubmed.ncbi.nlm.nih.gov/15345806/, https://pubmed.ncbi.nlm.nih.gov/15796163/, https://pubmed.ncbi.nlm.nih.gov/15084330/, https://pubmed.ncbi.nlm.nih.gov/17659826/, https://pubmed.ncbi.nlm.nih.gov/19100339/, https://pubmed.ncbi.nlm.nih.gov/21235521/, https://pubmed.ncbi.nlm.nih.gov/19534681/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509542/, https://pubmed.ncbi.nlm.nih.gov/29806132/, https://pubmed.ncbi.nlm.nih.gov/19594223/, https://pubmed.ncbi.nlm.nih.gov/17569207/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792534/, https://pubmed.ncbi.nlm.nih.gov/23281076/, https://pubmed.ncbi.nlm.nih.gov/21120596/, https://www.sciencedirect.com/science/article/abs/pii/S0300908415001777, Hemochromatosis Help Turmeric Supplements, Using Nutritional Supplements in Hemochromatosis, Supplements Created for the Hemochromatosis Patient, Benefits of Resveratrol in Hemochromatosis, Benefits of Milk Thistle in Hemochromatosis. All rights reserved. In their first study, they gave rabbits iron alone, or iron combined with BioPerine, and compared the iron absorption levels. Fundamentally, turmeric positively supports the way the body metabolizes and handles iron. Studies such as this look like a best-case scenario: highly effective at enhancing the absorption of a powerful nutrient (turmeric) with no adverse effects.. Take a look at the following graph and photo from a 2009 study evaluating the effect turmeric (aka curcumin) has on cellular iron levels: As you can clearly see, as levels of turmeric/curcumin increase, cellular iron levels decrease. Clinical evidence suggests this herbal remedy may be used as a complement to the most commonly recommended treatments for hemochromatosis: therapeutic phlebotomy and chelating medications. Vitamin C supplements (aids iron absorption). 16 Sterling Street, Asheville, North Carolina. If our bodies do the work from getting orders to the brain & cells from these supplements/inhibitors surely it must go into the waste, eg urine etc. All Rights Reserved. This study also demonstrates turmeric also has a powerful effect in reducing excess iron from our bloodstream, measured by markers such as plasma iron and transferrin saturation. Planta Med. There is one major challenge to using turmeric medicinally. Our other formulation of curcumin, Hemochromatosis Help Turmeric Cream, also does not use piperine. 2007 Nov;67(3):699-706. It has been 4 months now. The addition of piperine to iron increased the iron concentration significantly in the first 8 hours and continued to impact iron concentrations in the test subjects 60 hours later. Red meat. The challenge is how to get the turmeric into the cells of your body. In general, turmeric and its active constituent, curcumin, have been shown to be an excellent anti-inflammatory supplement. Powered by Help Scout. (**Note: In respect to the above study, our Turmeric Cream contains alcohol as an ingredient to enhance absorption). Published research and numerous articles online have repeated this 2000% statistic over and over to the point where it is essentially accepted that black-pepper-derived piperine is beneficial for people taking turmeric. Hemochromatosis Helps Turmeric Capsules provides the patented BCM-95 brand of turmeric, a special form of turmeric with enhanced methods of absorption. (**Note: In respect to the above study, our Turmeric Cream is a microemulsion preparation and not a amphiphillic preparation). Second is to use a special form of turmeric capsule with enhanced methods of absorption. In addition to turmerics ferritin and transferrin saturation lowering abilities, this herbal remedy has been shown by researchers to have many additional potential benefits to a person with iron overload. Definitely drink when you are thirsty. 2023. Simple blood tests can measure for elevations in these enzymes, which doctors monitor with care. You do raise a questionwhat is the ferritin life cycle? In addition to superior absorption, a topical skin application is easy and convenient to use. Powered by Help Scout. This study evaluated the effect in both human volunteers as well as animals. Antioxidant and anti-inflammatory properties of curcumin. How do you use turmeric for hemochromatosis? The ability of turmeric to absorb intestinal iron may lead to it being useful in states of iron overload, such as hemochromatosis, or hemolytic anemias, such as sickle cell disease.9 . Studies of curcumin and curcuminoides. Med.Chem. Once turmeric grabs hold of and chelates iron molecules, the turmeric then helps the body to excrete the iron. Where should I apply the Turmeric, Magnesium, or Calm & Relax Creams? Hegge AB1, Schller RB, Kristensen S, Tnnesen HH. You should consult with a health care professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. 2009 Feb;35(2):234-42. Obviously my main question to the consultants was that I understood, only when my levels/storage comes down through weekly venesection will the storage start to be taken from my good bit of liver or at the very least not worsen as cirrhosis from iron overload is irreversible. Fortunately, there are two optimal ways to absorb turmeric and therefore gain its exceptional benefits: First is to use a topical application a topical cream of turmeric gets absorbed directly into the body, bypassing the gut to ensure maximal results. After a certain amount of time, does it just kind of die and become waste? 2018 Sep;32(9):1828-1835.https://pubmed.ncbi.nlm.nih.gov/29806132/. The BCM-95 demonstrated an over 6-fold increase in turmeric absorption compared to the piperine version! 2008 Jul-Aug;70(4):445-9.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792534/, Shehzad A, Rehman G, Lee YS. 2003 May;55(5):593-601. To date, it has been the subject of more than 21 published studies and has been researched worldwide for over 12 years. Turmeric cream and HH any help in bringing down iron or saturation? Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Curcumin represses the synthesis of hepcidin, one of the peptides involved in iron balance, and has the potential to induce iron deficiency in the setting of prior subclinical iron deficiency [12]. Hemochromatosis Help Turmeric Cream $49.95 USD Turmeric is the best natural remedy shown by clinical research to reliably reduce the build-up of iron in the body Turmeric can lower ferritin by chelating iron from the body Turmeric is nature's best anti-inflammatory made better than ever before as a topical cream! Anyone have an experience with turmeric? Its primary activity is inside our cells, placing glutathione in a perfect position to neutralize free radicals. Once turmeric grabs hold of and chelates iron molecules, the turmeric then helps the body to excrete the iron. Copyright 2012 2023, Hemochromatosis Help. I used wheatgrass which has some valid clinical documentation. yes , when dealing with all these supplements, you get excited one minute , then down the next. On my body, I started using another cream as well as putting coconut oil and turmeric essential oil on my body at night. Paired with Scots new diet, gradually, he started to see a difference. The Turmeric Bundle features the two turmeric formulas on the My Hemochromatosis Help website with 5% savings by buying as a group. I have a high count, near 5000 and after two months it dropped by 1000. 4-1-2006;40(7):1152-1160.https://pubmed.ncbi.nlm.nih.gov/16545682/, Jiao, Y., Wilkinson, J., Di, X., Wang, W., Hatcher, H., Kock, N. D., DAgostino, R., Jr., Knovich, M. A., Torti, F. M., and Torti, S. V. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Despite turmerics promise of many health benefits, there is one major challenge to using turmeric medicinally. Research has also shown that turmeric increases the levels of a vital nutrient called glutathione! Despite turmerics promise of many health benefits, there is one major challenge to using turmeric medicinally. In addition to superior absorption, a topical skin application is easy and convenient to use. Your email address will not be published. Sure, piperine enhances turmeric absorption, but there is no way they can claim that there are no adverse effects based upon a study that lasted 4 hours long! Effective Doses Studies typically use doses of 5002,000 mg of turmeric per day, often in the form of an extract with a curcumin concentration that is much higher than the amounts naturally occurring in foods. First thought well if it goes into circulation, do you have to wait to be venesected ? J Pharmacol Exp Ther. Its medicine, food, and brilliant color all in one! As you can clearly see, as levels of turmeric/curcumin increase, cellular iron levels decrease. (A question for my hematologist in July). This study also demonstrates turmeric also has a powerful effect in reducing excess iron from our bloodstream, measured by markers such as plasma iron and transferrin saturation. Specifically, the names for the turmeric/curcumin ingredients in our product are: Tetrahydrodiferuloylmethane Tetrahydrodemethoxydiferuloylmethane Once turmeric grabs hold of and binds to an iron molecule, the turmeric then helps the body excrete the iron from your body. Not sure re : port but good luck. Iron-rich foods. 2006;136(12):2970-2974.https://pubmed.ncbi.nlm.nih.gov/17116705/, Baum, L. and Ng, A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimers disease animal models. Orientana - Natural Rich Face Cream Turmeric | 99.7% Natural Organic | Anti Aging Moisturiser For Women | Aloe Vera And Shea Butter | Firming & Hydrating Every Skin Type - 30g 71 1134 (37.80/100 g) Get it tomorrow, 19 May FREE Delivery by Amazon Options: 2 scents Altern Med Rev. Cancer Res Treat. Blackstrap molasses. All Rights Reserved. If turmeric is beneficial for iron overload and piperine enhances the absorption of turmeric, well, sign me up! I think in most people there is a small amount of that, but for those of us with HH, it has potential to be much worse. Hemochromatosis can be difficult to diagnose. This innovative product takes the naturally occurring essential oils from turmeric to synergistically enhance the absorption of the curcuminoids. Sign-up today for in-depth and empowering articles with actionable tips to assist you on your journey with hemochromatosis! Fang JY1, Hung CF, Chiu HC, Wang JJ, Chan TF. Patel NA1, Patel NJ, Patel RP. Another study found turmeric increased glutathione levels in the liver while markers of oxidative stress and iron levels were decreased. However, a deeper look at the situation just doesnt hold up. How poor? Since high iron levels contribute to oxidative stress, it makes sense that researchers have studied how glutathione levels interact with liver function. I started taking it and my numbers increased. The most useful one is age. Would you like to read hemochromatosis success stories? What you might not already know is that turmeric is also supremely beneficial for hemochromatosis. Oral absorption of curcumin is generally poor due to its low solubility and instability in the intestinal environment. Ordinary turmeric powders, pills, or teas, are only going to be used by your body a tiny amount. An extract from Black pepper known as piperine is a very common addition to turmeric supplements. Privacy Policy. Its beneficial because it effectively removes iron from the cells of the body and lowers ferritin levels. It is possible that 1020 M curcumin is more than enough to chelate all iron and that the remaining iron-free curcumin induces autophagy, enhancing neoplastic transformation44,47. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis.https://en.wikipedia.org wiki DeferoxamineDeferoxamine Wikipedia, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. . PMID: 23620848; PMCID: PMC3634921. Fortunately, turmeric is associated with improvements in some of the most commonly affected organs and tissues by high iron, including the liver, spleen, heart, brain, nervous system, and joints. What I found made me avoid it. Blood 1-8-2009;113(2):462-469.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615657/, Tuntipopipat, S., Zeder, C., Siriprapa, P., and Charoenkiatkul, S. Inhibitory effects of spices and herbs on iron availability. Other research has demonstrated that piperine may impact the metabolism of a wide range of medications. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. How much Turmeric is in your cream? - My Hemochromatosis Help Keep in mind these studies are very small and represent the only research on this topic, so we hope to see more extensive work to better understand this finding in the future. Until I was diagnosed with HH My storage has gone to my liver causing cirrhosis, my storgae was 94% and levels 1975. Why is turmeric helpful for hemochromatosis, you might ask? Posting lab numbers? I can only say that I had mixed results. Glutathione is one of the most important antioxidants in our bodies. I will also discuss the one major challenge to using turmeric medicinally and give you solutions so you can learn how to use this incredible herbal medicine correctly to make sure you receive its full benefits! Join our newsletter. 2013 Apr;3(4):253-66. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Article 21, Volume 3, Supplement 2, Autumn 2004, Pages 8-9. 2009;60 Suppl 1:43-55.https://pubmed.ncbi.nlm.nih.gov/18651292/, Tuntipopipat, S., Judprasong, K., Zeder, C., Wasantwisut, E., Winichagoon, P., Charoenkiatkul, S., Hurrell, R., and Walczyk, T. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. But to improve the taste and also ensure it is effectively absorbed by your body, we recommend combining turmeric with a liquid such as a flavoured turmeric shot, turmeric tea or smoothie.25 mar. Would you like to read hemochromatosis success stories? The whole iron process & storage is complex, so I won't claim to fully understand it. Thats exactly what the makers of BioPerine found in two small studies they conducted. Upgrade to Patient Pro Medical Professional? Use Two Types of Turmeric for the Best Golden Chicken. Am J Clin Nutr. One particular study demonstrated that glutathione reduces liver tissue damage, lowers liver enzymes, reduces inflammation, protects against oxidative damage, and possibly has iron chelation effects: To our surprise, glutathione reduced liver iron content and ferritin expression, denoting the possible iron chelation competency. Ive seen estimates that place turmerics absorption at about 5% so you are not likely absorbing much from diet alone. A community for the iron-overloaded. Renowned for centuries with a rich, historical use in plant and herbal medicine, turmeric has long been held in high regard for its beneficial effects. Chelate literally means to claw, and chelators are substances that work to remove the iron already stored in the body. But to also reduce the storage of too much iron?!? A deeper look shows a much different story. https://patient.info/forums/discuss/hemochromatosis-and-turmeric-570847. In other words, while we want to enhance turmeric absorption, we dont want to do this at the expense of liver detoxification function, enhanced iron absorption, and other potential long-term effects. A significant improvement in serum iron (could be correlated to the immediate release of iron from BioIron into systemic circulation); total iron binding capacity and serum ferritin level was also observed. Use of the forums is subject to our Terms of Use Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. Some individuals are sensitive to this ingredient. 2014 Jan;46(1):2-18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/, Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. A topical cream of turmeric gets absorbed directly into the body, bypassing the gut to ensure maximal results. Black tea. Seems USA have all the research universities !!!!! People with hereditary haemochromatosis - their hepcidin does not turn on to turn off the absorption of iron. Laboratory testing has shown BCM-95 greatly increases curcumin stability and significantly enhances oral absorption compared to ordinary curcumin. And there is other research that indicates that piperine might not be as perfect as people might think. 2009 Sep;5(5):474-82.https://pubmed.ncbi.nlm.nih.gov/19534681/, Milman NT. The turmeric cream does not stain the skin or clothes. and our How much curcumin does it take to chelate iron? Will the Turmeric Cream stain my clothes. From the reading I had done, it does come out of storage in the organ as the serum levels go down. Med Chem. I am curious if high cholesterol and HH are related. Once turmeric grabs hold of and binds to an iron molecule, the turmeric then helps the body excrete the iron from your body. 2023 My Hemochromatosis Help. Also, my veins can no longer sustain weekly phlebotomies and I am having a port inserted this weekanxious about this. Oxalic acid/oxalate does not seem to influence iron uptake. As we know, excess iron builds up in hemochromatosis, causing damage and leading to the symptoms and problems of iron overload. As turmeric/curcumin levels increased, iron levels decreased. Going to the organs is kind of a last resort thing to do. Mine was inflamed when I started and now is not inflamed at all. NTBI is also known as free iron and is the most likely form of iron to cause oxidative stress. J Nutr. The challenge is how to get the turmeric into the cells of your body. My cholesterol started going up 20 years ago and I finally started taking low dose Crestor this past fall which has brought it down to Normal. Our Hemochromatosis Help Turmeric Capsules features BCM-95, the very same ingredient studied above that showed the 6-fold increase in turmeric absorption! PMID: 19594223.https://pubmed.ncbi.nlm.nih.gov/19594223/, Menon VP, Sudheer AR. Hemochromatosis Help These statements have not been evaluated by the FDA. Were dedicated to providing you with the very best information about all kinds of subjects related to Fitness and nutrition, with an emphasis on improving your lifestyle and helping you become healthier.Founded in 2021 by Marie June, TheFitnessManual has come a long way from its beginnings. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. 2007;3(5):469-474.https://pubmed.ncbi.nlm.nih.gov/17897073/, Jiao, Y., Wilkinson, J., Christine, Pietsch E., Buss, J. L., Wang, W., Planalp, R., Torti, F. M., and Torti, S. V. Iron chelation in the biological activity of curcumin. Black pepper extracts of concentrated piperine are not the same as the black pepper you sprinkle on your food. What is the specific mechanism of action? It's a very mild off-white/yellow-colored cream, as opposed to the vibrant orange-yellow from turmeric root or powder. In addition to superior absorption, a topical skin application is easy and convenient to use. Renowned for centuries with a rich, historical use in plant and herbal medicine, turmeric has long been held in high regard for its beneficial effects. Heres how to get some, Primary Hemochromatosis Autosomal Dominant, Hemochromatosis Help Turmeric Cream Reviews, Reversible Complications Of Hemochromatosis, Can You Take Zinc If You Have Hemochromatosis. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Iranian Journal of Pharmaceutical Research. If you re-read the quote at the beginning of this article, they state, piperine, a known inhibitor of hepatic and intestinal glucuronidation.. I have found conflicting information about the effects of turmeric on HC. If you are taking certain supplements that make your urine yellow, then you can start out with the formula of drinking -1 ounce of water for each pound you weigh. Reddit, Inc. 2023. Has anyone used the turmeric cream and if so, did it bring down the iron and the saturation? Reddit and its partners use cookies and similar technologies to provide you with a better experience. I also read that turmeric cream is a chelator and will bring it down. Ive seen estimates that place turmerics absorption at only about 5%, so you are not likely absorbing much from diet alone. Specifically, the names for theturmeric/curcumin ingredients in our product are: The other ingredients are designed to create enhance absorption and create a stable, consistent product. as being in breach of those terms. A reduction in pain and fatigue alone would make the benefits of turmeric curcumin worth exploring. Now, this sounds like a better formula for success! How exactly does this relate to iron overload and nutrition? Raw seafood; raw shellfish might contain Vibrio Vulnificus, a bacteria deadly to people with high iron levels. PMID: 9619120. https://pubmed.ncbi.nlm.nih.gov/9619120/, Should We Be Weary of Piperine?, Invivo Healthcare, https://invivohealthcare.com/archives/should-we-be-wary-of-piperine/, Singh J, Dubey RK, Atal CK. Since glucuronidation is one of the most, if not The Most, critical liver detoxification pathways, we prefer not to interfere with it! I am 64-year old female who walks and/or bikes daily and have found out about this condition quite by accident as I am not having any issues and might just be one of the asymptomatic ones but it still could be doing damage to major organs. Curcumin, the active ingredient in turmeric, tends to be poorly absorbed by our digestive system. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. 16 Sterling Street, Asheville, North Carolina. $45.95 USD The Turmeric Bundle $89.95 USD $95.90 USD Medicinal Properties of Turmeric Turmeric is a beautiful, flavorful, commonly used spice in cooking. 2009 Jan;41(1):40-59.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/, Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin.
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