In some areas, the plant may tolerate temperatures as low as 50 degrees Fahrenheit (10 C). Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. The genus Justicia named after the 18th-century Scottish botanist James Justice is a flowering plant in the family Acanthaceae. Cut from the stem, some fresh or dried Justicia carnea leaves. Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities. Justicia pectoralis seems to have antibacterial and anti-inflammatory effects. Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. W Afr J Biol Sci. The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Justicia carnea and Cnidoscolus aconitifolius were tested for their capacity to ameliorate the fecundity of chloramphenicol-induced lymphoma in rats. The renal tubules and interstitial spaces appears distorted with presence of red inflammatory cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). Article The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). Biomed Environ Mass Spectrom 1988;15(8):413-417. Inter J Pharm Sci Res. White blood cell counts usually increases following foreign invaders (pathogens) resulting in normal body physiological response which boost the bodys defense mechanisms [28, 29]. This amazing, Coriander seeds as well as the leaves are widely used as spices in flavoring foods and drinks, and, Cashew leaves: health benefits and side effects of Anacardium occidentale, Fig leaves tea: Amazing benefits and best recipes, Negro pepper: 12 health benefits of uda seed and side effects. View abstract. It is a creeping, perennial plant and grows up to 2 meters tall. Google Scholar. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. The findings back up local assertions that they can be. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. To use the website as intended please CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. Lorke D. A new approach to practical acute toxicity testing. The plant has various other common names including: Back in the day, the Justicia flower was boiled and used to solve anemia problems. Antianaemic potentials of some plant extracts on phenyl hydrazineinduced anemia in rabbits. The absorbance of the supernatant was measured against reagent blank at 532nm. CAS It also increases good cholesterol levels. Mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) showed significant (p<0.05) increased at 50mg/kg while doses greater than 100mg/kg showed no significant difference compared to the control. The botanical name- Justicia carnea was coined after a scotish- James Justice, who happens to have found the plant first. However, coadministration of both extracts exerts a synergistic effecton the . Briefly, 1.0ml of the sample was mixed with 2ml of TCA-TBA-HCl reagent (0.37% thiobarbituric acid, 15% trichloroacetic acid and 0.24N HCl in 1:1:1) and boiled at 100C in a water bath for 15min. Toxicity studies of medicinal plants used in sub-Saharan Africa. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 2). The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. Research reports it isnt capable of causing kidney and liver damage either but dont eat it raw. Cover and leave for about fifteen minutes. 8-10 Justicia carnea leaves. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. J Ethnopharmacol 2000;70(2):151-159. 1999;9:18. Authors KOK and ESA performed the statistical analysis and managed the analyses of study. Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissues with Ellmans reagent. Extraction was carried out by maceration (72h) following the method of Onoagbe et al., [13]. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. BMC Complem Altern Med. The principle is based on the reduction of dichromate in a weak acid medium (acetic acid) to chromic acetate which is further heated in the presence of hydrogen peroxide to form an unstable intermediate (perchromic acid) that can be monitored spectrophotometrically at 620nm. Pharm. Acute toxicity was determined in two phases using Lorke method. As a consequence, depletion of reduced glutathione (GSH) either by removal from the cell or oxidation to GSSG could eventually lead to mild oxidative stress in cells and tissues [33, 34]. Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Colorimetric assay of catalase. In its native habitat, the Justicia carnea plant grows upright and may reach 3 5 feet tall. Relative to the control, liver of rats treated with doses of J. carnea ethanol extract showed varied degree of hepatic injury in a dose dependent manner. The renal effects of blood glucose-lowering plant-derived extracts in diabetes mellitus-an overview. Article 2005 - 2023 WebMD LLC, an Internet Brands company. Clin Phytosci 7, 2 (2021). Tietz NW. Acta Scientiarum Polonorum, Technologia Alimentaria. The indistinguishable differences of total protein in the liver and kidney of rats treated with ethanol extract of J. carnea could indicate that the plant extract did not alter protein synthetic function of the organs. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Nunes TRS, Cordeiro MF, Beserra FG, et al. However, lowest (50mg/kg) dose of extract significantly elevated MCH and MCHC. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties. The leaves were able to greatly lower the total cholesterol, LDL-cholesterol, and triglyceride levels, but increased the serum level of high density lipoprotein (HDL) cholesterol. Corroborating with the results of the antioxidant system and weight of the liver, continuous exposure to higher dose (1200mg/kg) of JCEE could result in hepatic damage. They are also needed in strong bone formation, and in cellular and neuronal functions. This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. This is . Catalase activity (U/ml) was measured following the method of Sinha [17]. Free radicals and antioxidants in normal physiological functions and human disease. 2013;1:38898. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. Aim. Studies on The Phytochemical and Nutritional Summer temperatures above 77 degrees Fahrenheit (25 C) are perfect. This information may not fit your specific health circumstances. In conclusion, oral acute administration of J. carnea ethanol extract is safe because neither mortality nor any signs of toxicity were observed in experimental rats. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. With exception of low doses that showed normal morphology of the hepatocyte and sinusoid that is not infiltrated, high doses of extract greater than 500mg/kg showed mild fat congestion in the central venules with liver parenchyma showing area of hemorrhage compared to the control. 2003;84:99104. The weight of liver and kidney of rats were measured immediately after excising the organs and is presented in Table2. The significant increase in MDA level at 1200mg/kg might be due to the presence of active secondary metabolites in the extracts that could have acted as prooxidant. This may be because of its hepatoprotective activity. I am a practicing medical doctor, a philosopher, critical thinker, a globalist, a patriot, SEO expert and a patient blogger. The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. Nutritional Composition of Ewe eje (Justicia carnea leaf). Decreased white blood cell count was obtained in this report, the level of lymphocyte and granulocyte was not altered by the extract while MID sized cell was significantly elevated at 500 and 800mg/kg dose. Total reaction mixture of 3ml contained 2.95ml of 0.05M sodium carbonate buffer (pH10.2), 0.02ml tissue sample and 0.03ml of epinephrine (2mM) in 0.005N HCl was used to initiate the reaction. Parameter that were determined include total haemoglobin concentration (HGB), packed cell volume (PCV), red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count (WBC), Lymphocyte count (LYM), MID sized cell (MID), Granulocyte Count (GRM) and platelet count (PLT). Oso BJ, Oyewo EB and Oladiji AT. Safety assessment of oral administration of ethanol extract of Justicia Consequently, the effects of the extract on MDA level could indicate damage to cell membrane lipids of the hepatocyte which could result to increased generation of reactive oxygen species (ROS). long (25 cm), and showy flower plumes, 8 in. The animals were allowed free access to rat chow and water ad libitum. Justicia carnea does not cause miscarriage or congenital birth defects. The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. Packed cell volume (PCV) and mean corpuscular volume (MCV) in treated rats with JCEE were statistically unperturbed compared to the control. While histology of organs showed no adverse pathological lesions in the internal organs of rats, higher dose (1200mg/kg) over a period of time could cause noticeable liver and kidney injury. Powdered sample was extracted using absolute ethanol and concentrated to obtain a slurry paste of J. carnea ethanol extracts. You can add milk or honey for taste before drinking. PubMed Central Antioxidants & redox signaling Forum Review. Buege JA, Aust SD. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. https://doi.org/10.1186/s40816-020-00234-4, DOI: https://doi.org/10.1186/s40816-020-00234-4. CAS These antibodies help prevent infections and fight off diseases. This study investigated the in-vitro antioxidant activity of ethanol leaf extract of Justicia carnea and its effect on antioxidant status of alloxan-induced diabetic albino rats. Google Scholar. Make sure to follow the package instructions carefully. Technical guidelines assembly of veterinary medicine research. Join now and start creating your dream garden! Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. Despite living in close proximity to this plant, many individuals may be unaware of its benefits. 32 years old (Greco et al., 1974), long-term treatment side effects are becoming more critical. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. Studies have also confirmed this claim. OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. J Ethnopharmacol. Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Yes my readers. Decoction of ewe eje or its leaf extract can lower serum cholesterol and get rid of bad cholesterol (LDL). When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. It does not tolerate low temperatures at all. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. This is in agreement with study of Anthonia et al., [21] who obtained LD50 above 5000mg/kg for aqueous extracts of J. carnea leaf. The findings show that ethanol extracts of Costus afer and Justicia carnea could operate as main antioxidants and free radical scavengers. Keep the soil moist, but not waterlogged. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. Pinch out tips to promote compact plants. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. This leaf replenishes your blood supply immediately. Phytochemical profile, antioxidant, -amylase inhibition, binding https://doi.org/10.35841/biomedicalresearch.30-18-666. Meth Enzymol. 2016;5(1):6270 https://doi.org/10.1016/j.joad.2015.08.006. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study.
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